Second patient cured of HIV

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The patient underwent a stem cell transplant from a donor with an HIV resistant gene.

Scientists today announced in the UK a cure for a second person infected with the disease virus by transplanting stem cells from a donor with an HIV-resistant gene.

The case, related to the medical journal The Lancet HIV, reported a patient from London, UK, who underwent treatment similar to the so-called “Berlin patient”, published in 2011, in Germany, as the first person infected with cured HIV , after receiving this therapy for three and a half years.

“We suggest that these results represent the second case of a person with HIV to be cured. The results show that the success of stem cell transplantation as a cure for HIV, first listed nine years ago in the ‘Berlin patient’, may be replicated, “he said, quoted in a statement by The Lancet, or coordinator of the experimental study, Ravindra Kumar Gupta, of the University of Cambridge.

According to a study, the “London patient”, a man, left his viral infection active after two and a half years without antiretroviral drugs.

Scientists have checked it in samples of blood, cerebrospinal fluid, semen, intestinal tissue and lymphoid.

Additionally, using a probabilistic model to calculate the percentage of cure, which would be 99% or even 90% of the immune cells derived from the cells that were transplanted.

In the case of “London patient”, the researchers concluded that 99% of his immune cells are derived from stem cells that receive the donor, or that it means that the stem cell transplant was successful. be monitored, albeit less frequently.

The research authors exclude treatment with stem cells – cells that differentiate into others and have a regenerative capacity – is at high risk and can only be used as the last resort used by viruses. on the side that have blood cancer.

“Therefore, it is not a treatment that can be widely given to HIV-infected people who are successfully responding to antiretroviral treatment,” said Ravindra Kumar Gupta.

The transplantation of donor stem cells with the HIV-resistant gene (CCR5) prevents the virus from multiplying in the infected person’s body, by replacing the donor’s immune cells with their immune cells. Radiotherapy and chemotherapy are used in parallel to eliminate traces of viruses.

Compared to “Berlin patient”, or “London patient” received less aggressive treatment, which consists of a single stem cell transplant and lower doses of chemotherapy and radiotherapy.

The “Berlin patient” underwent two transplants, radiation therapy throughout his body and a more intensive chemotherapy regimen.

Source: SIC Notícias

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