A recent finding has proven that teeth have the ability to regenerate, it seems, with the help of a drug called Tideglusib.
The drug, developed and tested to treat Alzheimer’s, appears to have an incredible second area of application, to repair the tooth cavities, and this has already been tested and proven in laboratory mice.
Tideglusib works by stimulating stem cells at the base of the tooth, which are the source of creation of dentin, which is nothing more than the mineralized substance that is affected creating cavities in the teeth.
It is not a novelty that the teeth, if given the right circumstances, can regenerate naturally and without any assistance, but for this it is necessary that the damage affects the pulp of the tooth, and then our body encourages the formation of new dentin.
But even in these cases, the tooth can only regenerate a thin layer of dentin, and this is not efficient in repairing cavities created by cavities, which are usually quite deep. Tideglusib, however, changes the picture by deactivating the enzyme GSK-3, which causes the production of dentin to be interrupted.
In the research, the team inserted small, biodegradable collagen sponges, impregnated with the drug into the wells, and these fostered dentine formation and within six weeks the damage was repaired, and with the collagen structure disappearing, only in place of the cavity an intact tooth.
All of this seems and is extremely interesting and promising, but it is worth once again to point out that until now these results have only been achieved when trying to repair the teeth in laboratory mice.
Nevertheless, since the drug has already been applied in humans for the treatment of Alzheimer’s disease and has had effects similar to those presented in tests carried out on laboratory rats, it is extremely likely that these results will be achieved in the tests performed in humans humans.